Clostridium difficile Infection in Adults and Children

[2017 new]

Introduction to this self-study CME activity


Annually more than 450,000 new cases of Clostridium difficile occur in healthcare settings in the United States. These infections significantly impact patient morbidity and mortality as well as costs associated with medical care. Early diagnosis and appropriate treatment of Clostridium difficile infections can improve patient outcomes and reduce associated costs of care. This self-study CME activity addresses the management of Clostridium difficile once infection is suspected in adult and pediatric hospitalized patients. 

Participants in this CME activity will understand and be able to implement an evidence-based approach to the care of patients with Clostridium difficile infections, standardizing and improving the quality of care for these patients. 


This self-study activity is appropriate for clinicians who provide care for patients with Clostridium difficile infections in inpatient settings.


Team Leaders

  • Tejal N. Gandhi, MD
    Infectious Diseases
  • Krishna Rao, MD
    Infectious Diseases

Team Members

  • Gregory Eschenauer, PharmD
  • John Y. Kao, MD
  • Andrea H. Kim, MD
    Internal Medicine
  • Megan Mack, MD
    Internal Medicine
  • Lena M. Napolitano, MD
  • F. Jacob Seagull, PhD
    Learning Health Sciences
  • David M. Somand, MD
    Emergency Medicine
  • Kathleen B. To, MD
  • Amanda M. Valyko
    Infection Control
  • Michael E. Watson, Jr., MD, PhD
    Pediatric Infectious Diseases
  • David Wesorick, MD
    Internal Medicine
  • Alison C. Tribble, MD
    Pediatric Infectious Diseases


  • Meghan A. Arnold, MD
    Pediatric Surgery
  • Daniel H. Teitelbaum, MD
    Pediatric Surgery
  • Laraine Lynn Washer, MD
    Infectious Diseases

Author Disclosures

Neither the team lead, the team members, nor the consultants have financial relationships with commercial companies whose products are discussed in this CME activity.

Other Acknowledgements

UMHS Guidelines Oversight Team

  • Grant Greenberg, MD, MA, MHSA
  • R. Van Harrison, PhD

Literature Search Services

  • Taubman Health Sciences Library

Production of Internet Format and Website Maintenance

  • Ellen Patrick-Dunlavey, MA

CME Accreditation and Credit Designation

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Michigan Medical School designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This CME activity was prepared for release in March 2017. CME credit may be awarded for a maximum of three years from its release date, specifically from March 1, 2017 through February 29, 2020. Continuation of credit from that date depends on a thorough review of the content currency and accuracy.

Method of Participation

  1. View the web pages. You may print the self-study text to read off-line.
  2. Complete the on-line learning assessment test with a score of 70% or higher.  After you initially take the test, the test will be immediately electronically scored. 
    If fewer than 70% of the questions are answered correctly, the questions that were not answered correctly will be noted in red.  Review the CME content related to those topics and retake the test.
    If 70% or more of the questions are answered correctly, the correct and incorrect answers for all questions will be shown along with explanations of the basis for the correct answer.  The link to register and receive credit is shown at the end of the items and explanations. 
  3. Complete the electronic credit request and activity evaluation.  An electronic certificate of participation will be provided immediately.
  4. Print the certificate of participation for your personal records.